三甲基硅烷化重氮甲烷合成路线

参考文献

Chemical and Pharmaceutical Bulletin, , vol. 34, # 8 p. 3273 - 3278

参考文献

IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
Location in patent: Page/Page column 151-152 ;
WO 2012/088469 A1

72925-16-7(R)-1-Boc-吡咯烷-3-甲酸+

18107-18-1三甲基硅烷化重氮甲烷

441717-40-4(R)-1-Boc-3-羧基吡咯烷甲酯

参考文献

WO2007/70398 A1, ;

Page/Page column 188 ;
WO 2007/070398 A1

117-34-02,2-二苯基乙酸+

18107-18-1三甲基硅烷化重氮甲烷

3469-00-9二苯基乙酸甲酯

参考文献

Noji, Masahiro; Sunahara, Haruka; Tsuchiya, Ken-Ichi; Mukai, Toru; Komasaka, Ayako; Ishii, Keitaro
Synthesis, 2008 , # 23 art. no. F16908SS, p. 3835 - 3845

24242-19-15-氨基烟酸+

18107-18-1三甲基硅烷化重氮甲烷

36052-25-25-氨基吡啶-3-羧酸甲酯

参考文献

BANYU PHARMACEUTICAL CO., LTD.; VERTEX PHARMACEUTICALS INCORPORATED; BINCH, Hayley; HASHIMOTO, Masaya; MORTIMORE, Michael; OHKUBO, Mitsuru; SUNAMI, Tomoko
Patent: WO2010/111056 A1, 2010 ;
Location in patent: Page/Page column 35-36 ;
WO 2010/111056 A1

93-51-62-甲氧基-4-甲基苯酚+

18107-18-1三甲基硅烷化重氮甲烷

494-99-53,4-二甲氧基甲苯

参考文献

Hitotsuyanagi, Yukio; Lee, Suguru; Ito, Izumi; Kondo, Kazuyuki; Takeya, Koichi; Yamagishi, Takehiro; Nagate, Takatoshi; Itokawa, Hideji
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 2 p. 213 - 217

6590-65-4N-(2-甲酰基苯基)-4-甲基苯磺酰胺+

18107-18-1三甲基硅烷化重氮甲烷

31271-90-6N-(对甲苯磺酰)吲哚

参考文献

Miyagi, Takashi; Hari, Yoshiyuki; Aoyama, Toyohiko
Tetrahedron Letters, 2004 , vol. 45, # 33 p. 6303 - 6305

453-71-44-氟-3-硝基苯甲酸+

18107-18-1三甲基硅烷化重氮甲烷

329-59-94-氟-3-硝基苯甲酸甲酯

参考文献

PFIZER PRODUCTS INC.
Patent: WO2008/84300 A1, 2008 ;
Location in patent: Page/Page column 22-23 ;
WO 2008/084300 A1

720-73-04-甲基-4-联苯基羧酸+

18107-18-1三甲基硅烷化重氮甲烷

49742-56-54’-甲基[1,1’-联苯]-4-甲酸甲酯

参考文献

Santhosh; Paul; De Clercq; Pannecouque; Witvrouw; Loftus; Turpin; Buckheit, Jr.; Cushman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 703 - 714

324028-85-55-甲氧基-6-硝基甲酸吡啶+

18107-18-1三甲基硅烷化重氮甲烷

390816-44-15-甲氧基-6-硝基吡啶甲酸甲酯

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 23 p. 6507 - 6514