1: in tetrahydrofuran; hexane T=0 - 20°C; 20 h; 2: With hydrogenchloride; water T=20°C; 0.5 h; 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
GLAXOSMITHKLINE LLC; HAYDAR, Simon N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann
Patent: WO2013/43553 A1, 2013 ;
Location in patent: Page/Page column 145 ;