1: 5-tert-butylfuran-2-carboxylic acid With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With 4-toluenesulfonyl azide in tetrahydrofuran; hexane
T=-78 - 0°C; 2 h;
3: diazomethyl-trimethyl-silane With potassium acetate
more than 3 stages;
参考文献
Bayer Pharmaceuticals Corporation; ONYX PHARMACEUTICALS, INC.
Patent: EP986382 B1, 2008 ;
Location in patent: Page/Page column 13; 22-23 ;
EP 0986382 B1
1: diazomethyl-trimethyl-silane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: pentanal With methanol in tetrahydrofuran; hexane
T=-78°C; 0.833333 h;
3: With dirhodium tetraacetate in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Aggarwal, Varinder K.; Sheldon, Chris G.; Macdonald, Gregor J.; Martin, William P.
Journal of the American Chemical Society, 2002 , vol. 124, # 35 p. 10300 - 10301
