2-联苯-(4-甲氧基)羧酸合成路线 （共 21 条）
反应条件
1: in tetrahydrofuran; diethyl ether T=-78 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1719756 A1, 2006 ;
Location in patent: Page/Page column 49 ;
EP 1719756 A1
反应条件
1: With palladium diacetate in water T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; 2: With potassium hydroxide in water T=20 - 75°C; 6 h;
参考文献
Korolev, Dmitrii N.; Bumagin, Nikolay A.
Tetrahedron Letters, 2006 , vol. 47, # 25 p. 4225 - 4229
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in acetonitrile T=90°C; Suzuki coupling reaction; 12 h;
参考文献
Tao, Bin; Goel, Subhash C.; Singh, Jagvir; Boykin, David W.
Synthesis, 2002 , # 8 p. 1043 - 1046
反应条件
1: With palladium diacetate in N,N-dimethyl-formamide T=60°C; Addition; 3 h; 2: With hydrogenchloride in N,N-dimethyl-formamide T=20°C; Hydrolysis;
参考文献
Xia, Min; Chen, Zhenchu
Synthetic Communications, 2000 , vol. 30, # 1 p. 63 - 68
反应条件
1: With sodium hydroxide in methanol T=20°C; Inert atmosphere; 2: With hydrogenchloride; water
参考文献
Wang, Congyang; Rakshit, Souvik; Glorius, Frank
Journal of the American Chemical Society, 2010 , vol. 132, # 40 p. 14006 - 14008
反应条件
C10H9Cl2N3O3Pd; potassium hydroxide in ethanol; water T=120°C; Suzuki Coupling; 0.0333333 h; Microwave irradiation;
参考文献
Shen, Liqun; Huang, Suyu; Nie, Yuanmei; Lei, Fuhou
Molecules, 2013 , vol. 18, # 2 p. 1602 - 1612
反应条件
sodium hydroxide in ethanol 18 h; Ambient temperature;
参考文献
Matsuhisa, Akira; Tanaka, Akihiro; Kikuchi, Kazumi; Shimada, Yoshiaki; Yatsu, Takeyuki; Yanagisawa, Isao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 11 p. 1870 - 1874
反应条件
1: 76 percent / aq. NaOH; KMnO4 / 3 h / 50 °C 2: 61 percent / aq. K2CO3 / Pd(PPh3)4 / acetonitrile / 12 h / 90 °C View Scheme
参考文献
Synthesis, , # 8 p. 1043 - 1046
反应条件
1: 79 percent / tetrahydrofuran / Ambient temperature 2: H2SO4 / methanol / 4 h / Heating 3: 4.5 N HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 3985 - 3992
反应条件
1: 79 percent / tetrahydrofuran / Ambient temperature 2: H2SO4 / methanol / 4 h / Heating 3: 4.5 N HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 3985 - 3992
