4-羟基-5-甲基-2-己酮合成路线 （共 7 条）
反应条件
L-proline in dimethyl sulfoxide; acetone T=20°C; Condensation; 48 h;
参考文献
Sakthivel; Notz; Bui; Barbas III
Journal of the American Chemical Society, 2001 , vol. 123, # 22 p. 5260 - 5267
反应条件
triethylamine; B-chloro-diisopinocampheylborane 1.) CH2Cl2, 0 deg C, 2 h; 2.) CH2Cl2, -78 deg C, 3 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tanimori, Shinji; Naka, Toshihito; Kirihata, Mitsunori
Synthetic Communications, 2004 , vol. 34, # 22 p. 4043 - 4048
反应条件
1H-imidazole T=25°C; 22 h; Reagent/catalyst;
参考文献
Szollosi, Gyoergy; Csampai, Antal; Somlai, Csaba; Fekete, Monika; Bartok, Mihaly
Journal of Molecular Catalysis A: Chemical, 2014 , vol. 382, p. 86 - 92
反应条件
1H-imidazole T=25°C; 22 h; Reagent/catalyst;
参考文献
Szollosi, Gyoergy; Csampai, Antal; Somlai, Csaba; Fekete, Monika; Bartok, Mihaly
Journal of Molecular Catalysis A: Chemical, 2014 , vol. 382, p. 86 - 92
反应条件
1: 4-methyl-4-hydroxypentan-2-one With L-proline in dimethyl sulfoxide T=20°C; 0.0833333 h; 2: isobutyraldehyde T=20°C; aldol reaction; 4 h; Title compound not separated from byproducts;
参考文献
Chandrasekhar; Reddy, N. Ramakrishna; Sultana, S. Shameem; Narsihmulu; Reddy, K. Venkatram
Tetrahedron, 2006 , vol. 62, # 2-3 p. 338 - 345
反应条件
sodium amalgam; water; Cu 1) HMPA; Multistep reaction. Title compound not separated from byproducts;
参考文献
Cinquini, Mauro
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 24, p. 39 - 72
反应条件
water; L-proline in N,N-dimethyl-formamide T=20°C; 216 h; Product distribution; Further Variations:SolventsReagentsreaction time;
参考文献
Nyberg, Annika I.; Usano, Annina; Pihko, Petri M.
Synlett, 2004 , # 11 p. 1891 - 1896
