N-[4-氯-2-(2,2,2-三氟乙酰基)苯基]-2,2-二甲基丙酰胺合成路线 (共 12 条)
反应条件
1: 3N aq. HCl 2: tetrahydrofuran 3: tetrahydrofuran View Scheme
参考文献
Young; Britcher; Tran; Payne; Lumma; Lyle; Huff; Anderson; Olsen; Carroll; Pettibone; O'Brien; Ball; Balani; Lin; Chen; Schleif; Sardana; Long; et al.
Antimicrobial Agents and Chemotherapy, 1995 , vol. 39, # 12 p. 2602 - 2605
反应条件
hydrogenchloride in dimethoxyethane (DME) Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2006/98969 A2, 2006 ;
Location in patent: Page/Page column 35-37 ;
WO 2006/098969 A2