4-(4-苯氧基苯基)-哌啶合成路线 （共 5 条）
反应条件
1: With trifluoroacetic acid T=130°C; 0.25 h; Microwave irradiation; 2: With hydrogen; palladium 10 on activated carbon in methanol T=75°C; P=3000.3 Torr; 5 h;
参考文献
INTERVET INTERNATIONAL B.V.
Patent: WO2009/77527 A1, 2009 ;
Location in patent: Page/Page column 62-63 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; Hydrogenation; 12 h;
参考文献
Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Miyajima, Atsuko Fukunaga Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2999 - 3002
反应条件
1.1: Mg / tetrahydrofuran 1.2: 77 percent / 1 h / 0 °C 2.1: 92 percent / TFA / CH2Cl2 / 12 h / 20 °C 3.1: 88 percent / H2 / Pd/C / methanol / 12 h / 20 °C View Scheme
参考文献
Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Miyajima, Atsuko Fukunaga Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2999 - 3002
反应条件
1.1: Mg / tetrahydrofuran 1.2: 77 percent / 1 h / 0 °C 2.1: 92 percent / TFA / CH2Cl2 / 12 h / 20 °C 3.1: 88 percent / H2 / Pd/C / methanol / 12 h / 20 °C View Scheme
参考文献
Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Miyajima, Atsuko Fukunaga Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2999 - 3002
反应条件
1: 92 percent / TFA / CH2Cl2 / 12 h / 20 °C 2: 88 percent / H2 / Pd/C / methanol / 12 h / 20 °C View Scheme
参考文献
Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Miyajima, Atsuko Fukunaga Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2999 - 3002
