hydrogenchloride; disodium octaborate; D-carbamoylase; air in dimethyl sulfoxide T=45°C; pH=8.02; 36 h;

1.1: 86 percent / aq. TFA / 20 °C 2.1: H2O / 2 h / 90 °C 2.2: 91 percent / aq. HCl / 21 - 90 °C 3.1: disodium tetraborate decahydrate; aq. NaOH; D-hydantoinase / dimethylsulfoxide / 45 h / 45 °C / pH 10.5 4.1: 73.8 g / disodium tetraborate decahydrate; aq. HCl; D-carbamoylase / air / dimethylsulfoxide / 36 h / 45 °C / pH 8.02 View Scheme

1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -70 - 10 °C 1.2: 33 percent / tetrahydrofuran; hexane / 20 °C 2.1: 86 percent / aq. TFA / 20 °C 3.1: H2O / 2 h / 90 °C 3.2: 91 percent / aq. HCl / 21 - 90 °C 4.1: disodium tetraborate decahydrate; aq. NaOH; D-hydantoinase / dimethylsulfoxide / 45 h / 45 °C / pH 10.5 5.1: 73.8 g / disodium tetraborate decahydrate; aq. HCl; D-carbamoylase / air / dimethylsulfoxide / 36 h / 45 °C / pH 8.02 View Scheme

1: 81 percent / methanol; H2O / 120 h / 20 °C 2: 63 percent / H2 / Pd/C / methanol; aq. HCl View Scheme

water; triethylamine in tetrahydrofuran T=20°C; 16 h;