Boc-d-2-茚烷甘氨酸合成路线 （共 4 条）
反应条件
water; triethylamine in tetrahydrofuran T=20°C; 16 h;
参考文献
Borthwick, Alan D.; Davies, Dave E.; Exall, Anne M.; Livermore, David G.; Sollis, Steve L.; Nerozzi, Fabrizio; Allen, Michael J.; Perren, Marion; Shabbir, Shalia S.; Woollard, Patrick M.; Wyatt, Paul G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6956 - 6969
反应条件
1: 73.8 g / disodium tetraborate decahydrate; aq. HCl; D-carbamoylase / air / dimethylsulfoxide / 36 h / 45 °C / pH 8.02 2: 96 percent / Et3N; H2O / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Borthwick, Alan D.; Davies, Dave E.; Exall, Anne M.; Livermore, David G.; Sollis, Steve L.; Nerozzi, Fabrizio; Allen, Michael J.; Perren, Marion; Shabbir, Shalia S.; Woollard, Patrick M.; Wyatt, Paul G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6956 - 6969
反应条件
1.1: 86 percent / aq. TFA / 20 °C 2.1: H2O / 2 h / 90 °C 2.2: 91 percent / aq. HCl / 21 - 90 °C 3.1: disodium tetraborate decahydrate; aq. NaOH; D-hydantoinase / dimethylsulfoxide / 45 h / 45 °C / pH 10.5 4.1: 73.8 g / disodium tetraborate decahydrate; aq. HCl; D-carbamoylase / air / dimethylsulfoxide / 36 h / 45 °C / pH 8.02 5.1: 96 percent / Et3N; H2O / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Borthwick, Alan D.; Davies, Dave E.; Exall, Anne M.; Livermore, David G.; Sollis, Steve L.; Nerozzi, Fabrizio; Allen, Michael J.; Perren, Marion; Shabbir, Shalia S.; Woollard, Patrick M.; Wyatt, Paul G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6956 - 6969
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -70 - 10 °C 1.2: 33 percent / tetrahydrofuran; hexane / 20 °C 2.1: 86 percent / aq. TFA / 20 °C 3.1: H2O / 2 h / 90 °C 3.2: 91 percent / aq. HCl / 21 - 90 °C 4.1: disodium tetraborate decahydrate; aq. NaOH; D-hydantoinase / dimethylsulfoxide / 45 h / 45 °C / pH 10.5 5.1: 73.8 g / disodium tetraborate decahydrate; aq. HCl; D-carbamoylase / air / dimethylsulfoxide / 36 h / 45 °C / pH 8.02 6.1: 96 percent / Et3N; H2O / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Borthwick, Alan D.; Davies, Dave E.; Exall, Anne M.; Livermore, David G.; Sollis, Steve L.; Nerozzi, Fabrizio; Allen, Michael J.; Perren, Marion; Shabbir, Shalia S.; Woollard, Patrick M.; Wyatt, Paul G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6956 - 6969
