1: With recombinant Alcaligenes faecalis penicillin G acylase immobilized on oxirane acrylic carrier; potassium hydroxide in water T=35°C; pH=10; 3 h; Enzymatic reaction; 2: With hydrogenchloride in water pH=1; optical yield given as percent eeenantioselective reaction;
(R)-15-aminomethyl-14-hydroxy-5,5-dimethyl-2,8-dithiolt;9gt;(2,5)pyridinophane; zinc diacetate; sodium methylate in methanol T=25°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 7 p. 1925 - 1928
