1: diethyl malonate With potassium tert-butylate in dimethyl sulfoxide T=20 - 30°C; 2: 5-chloro-2-nitro-4-trifluoromethyl-phenylamine in dimethyl sulfoxide T=60°C; 20 h; 3: With hydrogenchloride; potassium hydroxide; water more than 3 stages;
参考文献
McArthur, Silvia Gatti; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes
Patent: US2007/72879 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
US 20070072879 A1