1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; Substitution; 0.166667 h; 2: 1-(4-methoxyphenyl)-2-(4-methoxyphenyl)ethanone in N,N-dimethyl-formamide T=80°C; Substitution; 15 h;

1: With trichlorophosphate in dichloromethane Substitution; 5 h; Heating; 2: With water in tetrahydrofuran T=25°C; Hydrolysis; Title compound not separated from byproducts;

1.1: 91 percent / dimethylformamide / 18 h / Heating 2.1: POCl3 / CH2Cl2 / 5 h / Heating 2.2: H2O / tetrahydrofuran / 25 °C View Scheme

1: With trichlorophosphate T=20 - 80°C; 0.873333 h; Inert atmosphere; 2: With sodium acetate in water 0.5 h; Overall yield = 90 percent;