1: 2-chloro-pyrazine With iron (III) acetylacetonate in tetrahydrofuran Inert atmosphere; 2: n-propyl-magnesium chloride in tetrahydrofuran Cooling with ice-water; 3: With ammonium chloride in tetrahydrofuran; water T=20°C; Inert atmosphere;

hydrogen; sodium acetate; palladium on activated charcoal in methanol

1: 41 percent / POCl3 / 1 h / Heating 2: 24 percent / sodium acetate trihydrate, H2 / 5percent Pd on charcoal / methanol View Scheme