4'-甲氧基-N,N-二甲基联苯-4-胺合成路线 （共 20 条）
反应条件
potassium carbonate in ethanol; water T=80°C; Suzuki coupling; 0.166667 h; Microwave irradiation;
参考文献
Chtchigrovsky, Melanie; Lin, Yi; Ouchaou, Kahina; Chaumontet, Manon; Robitzer, Mike; Quignard, Francoise; Taran, Frederic
Chemistry of Materials, 2012 , vol. 24, # 8 p. 1505 - 1510
反应条件
N'-phenyl Urea; potassium carbonate; palladium diacetate in ethanol T=20°C; Suzuki reaction; 2 h;
参考文献
Cui, Xin; Zhou, Yuan; Wang, Na; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2007 , vol. 48, # 1 p. 163 - 167
反应条件
C35H31BrN4NiP in tetrahydrofuran T=70°C; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Guo, Wang-Jun; Wang, Zhong-Xia
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 1054 - 1061
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium lauryl sulfate; potassium carbonate; p-toluenesulfonyl chloride in water T=60°C; Suzuki Coupling;
参考文献
Liu, Jin-Biao; Zhou, He-Ping; Peng, Yi-Yuan
Tetrahedron Letters, 2014 , vol. 55, # 17 p. 2872 - 2875
反应条件
1: 4-bromo-N,N-dimethyl-aniline With lithium 2: With zinc(II) chloride 3: 1-methoxy-4-chlorobenzene With nickel phosphine amido pincer complex in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=70°C; Negishi cross-coupling; 12 h; Further stages.;
参考文献
Wang, Li; Wang, Zhong-Xia
Organic Letters, 2007 , vol. 9, # 21 p. 4335 - 4338
反应条件
Pd0(tris(tert-butyl)phosphine)2 in toluene T=90°C; Inert atmosphere;
参考文献
Denmark, Scott E.; Smith, Russell C.; Chang, Wen-Tau T.; Muhuhi, Joseck M.
Journal of the American Chemical Society, 2009 , vol. 131, # 8 p. 3104 - 3118
反应条件
1: p-MeOC6H4MnCl With IPr*hydrochloride; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=0°C; 0.5 h; 2: 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran T=0 - 25°C; 15 h;
参考文献
Leleu, Anne; Fort, Yves; Schneider, Raphael
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 9 p. 1086 - 1092
反应条件
1: p-anisylgermanium trichloride With sodium hydroxide in 1,4-dioxane; water T=20°C; 2: 4-bromo-N,N-dimethyl-aniline With palladium diacetate in 1,4-dioxane; water 0.5 h; Heating;
参考文献
Enokido, Tatsuki; Fugami, Keigo; Endo, Mayuko; Kameyama, Masayuki; Kosugi, Masanori
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1685 - 1688
反应条件
Ni(Cl){2-(Ph2P)C6H4NCH(Ph)P(O)Ph2} in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=25°C; Negishi coupling reaction; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Li; Wang, Zhong-Xia
Chemical Communications, 2011 , vol. 47, # 5 p. 1598 - 1600
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 0.0833333 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
