4'-甲氧基-N,N-二甲基联苯-4-胺合成路线 （共 20 条）
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 0.5 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
反应条件
stilbazo; palladium diacetate; potassium carbonate in water T=20°C; Suzuki-Miyaura cross-coupling reaction; Inert atmosphere;
参考文献
Peng, Yi-Yuan; Liu, Jinbiao; Lei, Xiaoli; Yin, Zenlan
Green Chemistry, 2010 , vol. 12, # 6 p. 1072 - 1075
反应条件
((C6H4)(PPh2)(NCHPhP(O)Ph2))NiCl in tetrahydrofuran T=70°C; Kumada cross-coupling; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10031 - 10038
反应条件
C35H31BrN4NiP in tetrahydrofuran T=25°C; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Guo, Wang-Jun; Wang, Zhong-Xia
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 1054 - 1061
反应条件
C27H22Cl2N3NiP in tetrahydrofuran; 1-methyl-pyrrolidin-2-one 12 h; Inert atmosphereSchlenk techniqueHeating;
参考文献
Zhang, Qiang; Zhang, Xue-Qi; Wang, Zhong-Xia
Dalton Transactions, 2012 , vol. 41, # 34 p. 10453 - 10464,12
反应条件
1: di(4-methoxyphenyl)-borinic acid With KHF2 in methanol 2: 4-bromo-N,N-dimethyl-aniline With sodium carbonate; triphenylphosphine; palladium diacetate in 2-methoxy-ethanol Suzuki-Miyaura reaction; Heating;
参考文献
Ito, Takatoshi; Iwai, Toshiyuki; Mizuno, Takumi; Ishino, Yoshio
Synlett, 2003 , # 10 p. 1435 - 1438
反应条件
1: 4-Me2NC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran T=25°C; 0.25 h; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Boehner, Christine M.; Frye, Elizabeth C.; O'Connell, Kieron M. G.; Galloway, Warren R. J. D.; Sore, Hannah F.; Dominguez, Patricia Garcia; Norton, David; Hulcoop, David G.; Owen, Martin; Turner, Gillian; Crawford, Claire; Horsley, Helen; Spring, David R.
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13230 - 13239
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 1,4-di(diphenylphosphino)-butane; potassium hydroxide in water; tert-butyl alcohol T=90°C; 16 h;
参考文献
Boehner, Christine M.; Frye, Elizabeth C.; O'Connell, Kieron M. G.; Galloway, Warren R. J. D.; Sore, Hannah F.; Dominguez, Patricia Garcia; Norton, David; Hulcoop, David G.; Owen, Martin; Turner, Gillian; Crawford, Claire; Horsley, Helen; Spring, David R.
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13230 - 13239
反应条件
1: N,N-dimethyl-formamide / 20 °C / |Inert atmosphere; |Schlenk technique 2: C27H22Cl2N3NiP / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 12 h / |Inert atmosphere; |Schlenk technique; |Heating View Scheme
参考文献
Zhang, Qiang; Zhang, Xue-Qi; Wang, Zhong-Xia
Dalton Transactions, 2012 , vol. 41, # 34 p. 10453 - 10464,12
反应条件
1.1: aq. HCl 2.1: KHF2 / methanol 2.2: PPh3; aq. Na2CO3 / Pd(OAc)2 / 2-methoxy-ethanol / Heating View Scheme
参考文献
Ito, Takatoshi; Iwai, Toshiyuki; Mizuno, Takumi; Ishino, Yoshio
Synlett, 2003 , # 10 p. 1435 - 1438
