1: ethyl acetate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=20°C;
2: tert-butyldimethylsilyl chloride With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Wenzel, Anna G.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 44 p. 12964 - 12965
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542