1: imidazole / dimethylformamide / 0 - 20 °C 2: 55 percent / KOH / tetrahydrofuran; methanol; H2O / 0.5 h / -10 - 5 °C View Scheme
参考文献
Schauder, Jean-Roch; Jendrezejewski, Stefan; Neidhart, Werner L.; Hart, Graham J.; Battersby, Alan R.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2691 - 2698
1: 1-Benzyl-4-piperidon-3-carbonsaeuremethylester With 1H-imidazole; tert-butyldimethylsilyl chloride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: With lithium aluminium tetrahydride in diethyl ether T=0°C; 1.5 h; 3: tert-butyldimethylsilyl chloride With 1H-imidazole; methanol more than 3 stages;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1726590 A1, 2006 ;
Location in patent: Page/Page column 59 ;