反应条件
1: (1-(tert-butoxycarbonyl)-(4S)-fluoro-(2R)-pyrrolidinyl)acetonitrile With sodium hydride in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; Metallation; 0.5 h; 2: (2R)-N-triphenylmethyl-3-iodoalanine methyl ester in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=40°C; Substitution; cyclization; 12 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 6067 - 6070
