1,3-二苯基-2-丙炔-1-醇合成路线 （共 82 条）
反应条件
n-butyllithium; lithium azide; methanesulfonyl chloride; copper(l) chloride; lithium bromide
1.) THF, -60 deg C; 2.) THF, DMF, -60 deg C, overnight; Yield given. Multistep reaction;
参考文献
L'abbe, Gerrit; Mahy, Michel; Bollyn, Marcus; Germain, Gabriel; Scheefer, Guy
Bulletin des Societes Chimiques Belges, 1983 , vol. 92, # 10 p. 881 - 892
反应条件
1.1: BuLi / hexane; tetrahydrofuran / 0.17 h / -78 °C
1.2: 64 percent / hexane; tetrahydrofuran / -78 - 20 °C
2.1: 1.38 g / aq. KOH / methanol / 16 h
View Scheme
参考文献
Wessig, Pablo; Mueller, Gunnar; Herre, Robert; Kuehn, Andreas
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2694 - 2719
参考文献
Wessig, Pablo; Mueller, Gunnar; Pick, Charlotte; Matthes, Annika
Synthesis, 2007 , # 3 p. 464 - 477
反应条件
1: TBTU; (i-Pr)2NEt
View Scheme
参考文献
Wessig, Pablo; Mueller, Gunnar; Herre, Robert; Kuehn, Andreas
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2694 - 2719
反应条件
1: 1-phenyl-3-phenyl-propyn-3-ol With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.166667 h;
2: ethyl bromoacetate in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Wessig, Pablo; Mueller, Gunnar; Herre, Robert; Kuehn, Andreas
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2694 - 2719
反应条件
1: With anhydrous iron chloride; Benzsulfohydroxamic acid in dichloromethane
1.5 h; Reflux;
2: With triethylamine in dichloromethane
3 h; Reflux;
参考文献
Debleds, Olivier; Gayon, Eric; Ostaszuk, Emilie; Vrancken, Emmanuel; Campagne, Jean-Marc
Chemistry - A European Journal, 2010 , vol. 16, # 40 p. 12207 - 12213
反应条件
hydrogen; palladium-copper; silica gel in ethanol
T=25°C; P=760.051 Torr;
参考文献
Spee; Boersma; Meijer; Slagt; Van Koten; Geus
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1647 - 1656
反应条件
hydrogen; palladium-copper; silica gel in ethanol
T=25°C; P=760 Torr; Kinetics;
参考文献
Spee; Boersma; Meijer; Slagt; Van Koten; Geus
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1647 - 1656
反应条件
triethylamine in tetrahydrofuran
T=0 - 20°C; 0.5 h;
参考文献
Yoshizawa, Kazuhiro; Shioiri, Takayuki
Tetrahedron, 2007 , vol. 63, # 27 p. 6259 - 6286
反应条件
iodine; 1,1,1,3,3,3-hexamethyl-disilazane in dichloromethane
T=0 - 20°C; 0.583333 h; Inert atmosphere;
参考文献
Rubial, Belen; Ballesteros, Alfredo; Gonzalez, Jose M.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3337 - 3343
