4-苯基-3-丁炔-2-酮合成路线 （共 131 条）
反应条件
1: pyridine; hydroxylamine hydrochloride; sodium sulfate / 17 h / Reflux 2: iodine cloride / dichloromethane / 20 °C View Scheme
参考文献
Kalin, Jay H.; Zhang, Hankun; Gaudrel-Grosay, Sophie; Vistoli, Giulio; Kozikowski, Alan P.
ChemMedChem, 2012 , vol. 7, # 3 p. 425 - 439
反应条件
2: N,N-dimethylaminopyridine (DMAP), Et3N / CH2Cl2 / 3 h / Ambient temperature 3: H2, quinoline / Pd (5percent on BaSO4) / 1.5 h 5: 1.) boron trifluoride 2.) aq. sodium hydrogen carbonate / 1.) AcOH, CH2Cl2, 20 deg C, 1.5 h 2.) 15 min 6: Et3N, m-chloroperbenzoic acid / diethyl ether / 20 h / Ambient temperature View Scheme
参考文献
Fleming, Ian; Higgins, Dick; Lawrence, Nicholas J.; Thomas, Andrew P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 24 p. 3331 - 3350
反应条件
sodium hydride 1.) DMF, RT, 2 h; 2.) DMF, 3 h, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Rudorf, Wolf-Dieter; Schwarz, Ralf
Tetrahedron Letters, 1987 , vol. 28, # 37 p. 4267 - 4270
反应条件
1: 100 percent / CsF; TBAF / 1,2-dimethoxy-ethane / 25 °C 2: aq. HCl / tetrahydrofuran View Scheme
参考文献
Manandhar, Sudha; Singh, Rajendra P.; Shreeve, Jean'ne M.
Collection of Czechoslovak Chemical Communications, 2002 , vol. 67, # 9 p. 1296 - 1304
反应条件
potassium hydroxide in dichloromethane; water T=5 - 25°C; 1 h; Large scale; Solvent;
参考文献
Zanka, Atsuhiko; Hashimoto, Norio; Uematsu, Ryoichi; Okamoto, Takumi
Organic Process Research and Development, 1998 , vol. 2, # 5 p. 320 - 324
反应条件
potassium carbonate in tetrahydrofuran Ambient temperature;
参考文献
Miki, Yasuyoshi; Nakamura, Noriko; Hachiken, Hiroko; Takemura, Shoji
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1739 - 1745
反应条件
sodium hydride 1.) DMF, RT, 2 h; 2.) DMF, 3 h, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Rudorf, Wolf-Dieter; Schwarz, Ralf
Tetrahedron Letters, 1987 , vol. 28, # 37 p. 4267 - 4270
反应条件
sodium hydride 1.) DMF, RT, 2 h; 2.) DMF, 3 h, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 28, # 37 p. 4267 - 4270
反应条件
1: methanol / -30 °C
2: HCl; H2O / butan-1-ol / Heating
View Scheme
参考文献
Ananchenko; Petrov; Ershov
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 1 p. 153 - 154
反应条件
ethanol; acetic acid
参考文献
v. Auwers; Stuhlmann
Chemische Berichte, 1926 , vol. 59, p. 1054
