2-(1-二苯甲基氮杂啶-3-基)丙二酸二乙酯合成路线 （共 9 条）
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 1-benzhydryl-3-methanesulfonyloxyazetidine in tetrahydrofuran 18 h; Reflux;
参考文献
Faust, Mark R.; Hoesl, Cornelia E.; Wanner, Klaus T.
Heterocycles, 2008 , vol. 75, # 12 p. 2981 - 2988
反应条件
sodium hydrogencarbonate; citric acid in tetrahydrofuran; hexane
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US5849757 A1, 1998 ;
反应条件
1: 89 percent / pyridine 2: 81 percent / LiBr, Li2CO3 / tetrahydrofuran 3: 1.) NaH / 1.) DMF, 2.) DMF View Scheme
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
反应条件
1: 81 percent / LiBr, Li2CO3 / tetrahydrofuran 2: 1.) NaH / 1.) DMF, 2.) DMF View Scheme
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
反应条件
sodium hydride 1.) DMF, 2.) DMF; Yield given. Multistep reaction;
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
反应条件
1: 99 percent / H2 / 20percent Pd(OH)2 on C / ethyl acetate / 14 h / 760 Torr 2: 89 percent / aq. KOH / ethanol / 20 h / Ambient temperature View Scheme
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
反应条件
hydrogen; palladium hydroxide - carbon in ethyl acetate P=760 Torr; 14 h;
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
反应条件
1: 60 percent / aq. KOH / ethanol / 16 h / Ambient temperature 2: 83 percent / 2 h / 130 °C / 2 Torr 3: 59 percent / H2 / 20percent Pd(OH)2 on C / methanol / 18 h / 2585.7 Torr View Scheme
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
反应条件
1: 99 percent / H2 / 20percent Pd(OH)2 on C / ethyl acetate / 14 h / 760 Torr 2: 89 percent / aq. KOH / ethanol / 20 h / Ambient temperature 3: 23 percent / 0.17 h / 160 - 170 °C / 1 Torr View Scheme
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
