1,4-双(N-Boc)哌嗪-2-甲酸合成路线 （共 14 条）
反应条件
1: 85 percent / BH3*THF / tetrahydrofuran / 2 h / 50 °C 2: 17.6 g / NaH / tetrahydrofuran; various solvent(s) / Heating View Scheme
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
反应条件
1: 85 percent / BH3*THF / tetrahydrofuran / 2 h / 50 °C 2: 17.6 g / NaH / tetrahydrofuran; various solvent(s) / Heating 3: 9 percent / n-BuLi / hexane / Heating View Scheme
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
反应条件
caesium carbonate in ethyl acetate; acetonitrile
参考文献
SYMPHONY EVOLUTION, INC.
Patent: US2011/82114 A1, 2011 ;
US 20110082114 A1
反应条件
methanol in dichloromethane T=2 - 20°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/148853 A1, 2008 ;
Location in patent: Page/Page column 158 ;
WO 2008/148853 A1
