4-(4-氯苯基)-1,2,3-噻二唑合成路线 （共 6 条）
反应条件
thionyl chloride
T=20 - 60°C; 4 h;
参考文献
Kumar, Anil; Muthyala, Manoj Kumar; Choudhary, Sunita; Tiwari, Rakesh K.; Parang, Keykavous
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9391 - 9396,6
反应条件
thionyl chloride
T=0 - 20°C;
参考文献
Hayat, Faisal; Salahuddin, Attar; Zargan, Jamil; Azam, Amir
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 6127 - 6134
反应条件
thionyl chloride; toluene-4-sulfonic acid; hydrazinecarboxylic acid ethyl ester
1.) toluene, reflux, 2 h, 2.) 60 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Thomas; Nishizawa; Zimmermann; Williams
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 442 - 446
反应条件
thionyl chloride
T=0 - 5°C;
参考文献
Butler, Richard N.; O'Donoghue, Denis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1223 - 1228
反应条件
1: 57 percent / conc. H2SO4 / 120 h / Ambient temperature
2: 55 percent / 1 N NaOH / 0.25 h / Ambient temperature
View Scheme
参考文献
L'abbe, Gerrit; Frederix, Ann
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1415 - 1418
参考文献
Raap,R.; Micetich,R.G.
Canadian Journal of Chemistry, 1968 , vol. 46, p. 1057 - 1063
