2-[[[(1,1-二甲基乙氧基)羰基]氨基]甲基]-4-噁唑羧酸甲酯合成路线 （共 7 条）
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrachloromethane; acetonitrile 3 h; Ambient temperature; Yield given;
参考文献
Deeley, Jon; Bertram, Anna; Pattenden, Gerald
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 11 p. 1994 - 2010
反应条件
1: With [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=-20°C; 0.5 h; 2: With trichloromonobromomethane in dichloromethane T=2 - 3°C; 8 h;
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/054510 A1
反应条件
1: With diethylamino-sulfur trifluoride in dichloromethane T=-78°C; 2: With trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene T=0°C;
参考文献
Organic Letters, , vol. 13, # 4 p. 680 - 683
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=-10°C; 0.166667 h; Inert atmosphere; 2: With trichloromonobromomethane in dichloromethane T=-10 - 20°C; Inert atmosphere;
参考文献
Loos, Patrick; Ronco, Cyril; Riedrich, Matthias; Arndt, Hans-Dieter
European Journal of Organic Chemistry, 2013 , # 16 p. 3290 - 3315
反应条件
1: 89 percent / aq. Et3N / tetrahydrofuran / Ambient temperature 2: 85 percent 3: CHCl3 4: DBU, pyridine / acetonitrile; CCl4 / 3 h / Ambient temperature View Scheme
参考文献
Videnov, Georgi; Kaiser, Dietmar; Kempter, Christoph; Jung, Guenther
Angewandte Chemie, 1996 , vol. 108, # 13/14 p. 1604 - 1607
反应条件
1: 85 percent 2: CHCl3 3: DBU, pyridine / acetonitrile; CCl4 / 3 h / Ambient temperature View Scheme
参考文献
Videnov, Georgi; Kaiser, Dietmar; Kempter, Christoph; Jung, Guenther
Angewandte Chemie, 1996 , vol. 108, # 13/14 p. 1604 - 1607
反应条件
1.1: triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 2.1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / dichloromethane / 0.5 h / -20 °C 2.2: 8 h / 2 - 3 °C View Scheme
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
WO 2012/054510 A1
