6-甲氧基苯并噻吩-2-硼酸合成路线 （共 6 条）
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-60°C; 0.5 h;
参考文献
Eli Lilly And Company
Patent: US6350774 B1, 2002 ;
Location in patent: Page column 48 ;
US 6350774 B1
反应条件
n-butyllithium in tetrahydrofuran; diethyl ether
参考文献
Eli Lilly and Company
Patent: US5856340 A1, 1999 ;
反应条件
1.1: K2CO3 / acetone 1.2: BF3*Et2O 2.1: BuLi 2.2: B(OiPr)3 2.3: HCl View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401
反应条件
1: Na2CO3; Pd(PPh3)4 2: BBr3 View Scheme
参考文献
Schopfer, Ulrich; Schoeffter, Philippe; Bischoff, Serge F.; Nozulak, Joachim; Feuerbach, Dominik; Floersheim, Philipp
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1399 - 1401
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water T=110°C; Suzuki coupling; 12 h; Ionic liquidInert atmosphere;
参考文献
Shinde, Pravin S.; Shinde, Sandip S.; Renge, Atul S.; Patil, Gajanan H.; Rode, Ambadas B.; Pawar, Rajendra R.
Letters in Organic Chemistry, 2009 , vol. 6, # 1 p. 8 - 10
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate Suzuki coupling reaction;
参考文献
Schopfer, Ulrich; Schoeffter, Philippe; Bischoff, Serge F.; Nozulak, Joachim; Feuerbach, Dominik; Floersheim, Philipp
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1399 - 1401
