3,4-二羟基噻吩-2,5-二羧酸二乙酯合成路线 （共 16 条）
反应条件
sodium ethanolate in ethanol T=68°C; 1 h; Microwave irradiation; WavelengthTime;
参考文献
Far Eastern New Century Corporation; Liang, Nai-Yun; Tsai, Hui-Shan; Ke, Ching-Wei; Jseng, Chin-Wan
Patent: EP2548875 A1, 2013 ;
Location in patent: Paragraph 0074-0082 ;
反应条件
hydrogenchloride in water
参考文献
WO2008/106194 A1, ;
Page/Page column 7-9 ;
反应条件
1: 78 percent / potassium carbonate / dimethylformamide / 150 °C 2: 83 percent / potassium hydroxide / ethane-1,2-diol / 2 h / 100 °C View Scheme
参考文献
Coffey; McKellar; Reinhardt; Nijakowski; Feld
Synthetic Communications, 1996 , vol. 26, # 11 p. 2205 - 2212
反应条件
sodium hydroxide; water; sodium acetate T=110°C;
参考文献
Du Pont de Nemours and Co.
Patent: US2453102 , 1944 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=160°C; Williamson Ether Synthesis; 0.333333 h; Microwave irradiation; Wavelength;
参考文献
Far Eastern New Century Corporation; Liang, Nai-Yun; Tsai, Hui-Shan; Ke, Ching-Wei; Jseng, Chin-Wan
Patent: EP2548875 A1, 2013 ;
Location in patent: Paragraph 0083-0088 ;
反应条件
tributylphosphine; diethylazodicarboxylate in tetrahydrofuran T=66°C; Mitsunobu reaction; 6 h;
参考文献
Zong, Kyukwan; Madrigal, Luis; Groenendaal; Reynolds, John R.
Chemical Communications, 2002 , # 21 p. 2498 - 2499
反应条件
in tetrahydrofuran; ethylene glycol
参考文献
AGFA-GEVAERT
Patent: US2003/162958 A1, 2003 ;
反应条件
in tetrahydrofuran; ethylene glycol
参考文献
AGFA-GEVAERT
Patent: US2003/162958 A1, 2003 ;
反应条件
sodium ethanolate 1.) ethanol, 1 h, reflux; 2.) 24 h, 110 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Holzer, W.; Schmid, E.; Slatin, C.
Monatshefte fuer Chemie, 1994 , vol. 125, # 11 p. 1287 - 1292
反应条件
1: potassium carbonate / dimethylformamide / Heating View Scheme
参考文献
Coffey; McKellar; Reinhardt; Nijakowski; Feld
Synthetic Communications, 1996 , vol. 26, # 11 p. 2205 - 2212
