5-(氯甲基)-3-苯基-1,2,4-氧二唑合成路线 （共 16 条）
反应条件
triethylamine in benzene 10 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 48, p. 296 - 304
反应条件
triethylamine in ethyl acetate; toluene
参考文献
US6166020 A1, ;
US 6166020 A
反应条件
in toluene 2 h; RefluxMolecular sieve;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 10 p. 3783 - 3805
反应条件
1: NH2OH*HCl; Et3N / ethanol / Heating 2: DIEA / 1,2-dichloro-ethane / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 2 p. 302 - 306
反应条件
1: iPr2NEt / CH2Cl2 / 0 °C 2: 50 percent / n-Bu4NF / tetrahydrofuran / 18 h / 23 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 8 p. 1441 - 1443
反应条件
in benzene 5 h; Heating;
参考文献
Synthetic Communications, , vol. 22, # 2 p. 209 - 217
反应条件
1: With sodium carbonate in chloroform 2.25 h; 2: in o-xylene 3 h; Heating; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2815 - 2824
参考文献
Journal of Organic Chemistry, , vol. 36, p. 1306 - 1307
参考文献
Chemische Berichte, , vol. 105, p. 2825 - 2840
反应条件
(i) hexamethylenetetramine, CHCl3, (ii) aq. HCl, EtOH; Multistep reaction;
参考文献
Palazzo,G. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, # 2 p. 351 - 367
