4-(N-苄氧羰基)-氨基哌啶合成路线 （共 4 条）
反应条件
hydrogenchloride in methanol; water T=20°C; 23 h;
参考文献
Eisai RandD Management Co., Ltd.; YOSHIDA Ichiro; OKABE Tadashi; MATSUMOTO Yasunobu; WATANABE Nobuhisa; OHASHI Yoshiaki; ONIZAWA Yuji; HARADA Hitoshi
Patent: EP2757103 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1-chloroethyl chlorocarbonate in dichloromethane T=20°C; 3 h;
参考文献
US2003/232847 A1, ;
Page 14 ;
US 20030232847 A1
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane; water / 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 3 p. 1021 - 1046
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere View Scheme
