8-[(S)-羟基[4-苄基氧基苯基]甲基]-1,4-二氧杂螺[4.5]癸烷-8-羧酸乙酯合成路线 （共 3 条）
反应条件
trimethylaluminum 1) CH2Cl2, toluene, rt, 30 min; 2) CH2Cl2, toluene. 50-55 deg C, 2 d; Yield given. Multistep reaction;
参考文献
Wu, Guangzhong; Tormos, Wanda
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6412 - 6414
反应条件
1: 1.) Me3Al / 1) CH2Cl2, toluene, rt, 30 min; 2) CH2Cl2, toluene. 50-55 deg C, 2 d 2: BnNEt3Cl, (EtO)2P(O)Cl, aq. NaOH / CH2Cl2 / 2 h / Ambient temperature 3: toluene; various solvent(s) / 1.5 h / 48 - 52 °C / further solvents and temperatures View Scheme
参考文献
Wu, Guangzhong; Tormos, Wanda
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6412 - 6414
反应条件
1: 1.) Me3Al / 1) CH2Cl2, toluene, rt, 30 min; 2) CH2Cl2, toluene. 50-55 deg C, 2 d
2: BnNEt3Cl, (EtO)2P(O)Cl, aq. NaOH / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Wu, Guangzhong; Tormos, Wanda
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6412 - 6414
