1,3,5-三(溴甲基)苯合成路线 （共 27 条）
反应条件
sodium azide in dimethyl sulfoxide
T=20°C; 18 h;
参考文献
Sander, Fabian; Fluch, Ulrike; Hermes, Jens Peter; Mayor, Marcel
Small, 2014 , vol. 10, # 2 p. 349 - 359
反应条件
1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h
2: 85percent aq. KOH / 16 h / Heating
3: 3 h / 100 - 180 °C
View Scheme
参考文献
Yamagiwa, Yoshiro; Koreishi, Yoshiro; Kiyozumi, Satoshi; Kobayashi, Masanori; Kamikawa, Tadao; Tsukino, Mitsuji; Goi, Hironori; Yamamoto, Mikiko; Munakata, Megumu
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 11 p. 3317 - 3323
反应条件
1: 71 percent / 18-crown-6 / toluene / 24 h / 100 °C
2: 53 percent / hydrazyne hydrate; HCl / ethanol; toluene / 72 h / Heating
View Scheme
参考文献
Grawe, Thomas; Schrader, Thomas; Gurrath, Marion; Kraft, Arno; Osterod, Frank
Organic Letters, 2000 , vol. 2, # 1 p. 29 - 32
反应条件
triethylamine
4 h; Heating;
参考文献
Kishore, Kaushal; Verneker, Vencatesh R. Pal; Dharumaraj, Gnanasihamony V.
Journal of Chemical & Engineering Data, 1984 , vol. 29, # 3 p. 369
反应条件
acetone; sodium iodide
参考文献
Delepine, Anne-Sophie; Tripier, Raphael; Bernard, Helene; Bris, Nathalie Le; Handel, Henri
Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2521 - 2524
反应条件
18-crown-6 ether; potassium carbonate in acetone
24 h; Heating;
参考文献
Krishna Maiti, Amiya; Martinez, Ricardo; Mestres, Ramon; Tortajada, Amparo; Villar, Felix
Tetrahedron, 2001 , vol. 57, # 16 p. 3397 - 3401
反应条件
(i) Mg, I2, Et2O, (ii) /BRN= 1867329/; Multistep reaction;
参考文献
Eisenbraun,E.J. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 1967 - 1972
