2,2,2-三氟-1-(4-羟基苯基)乙酮合成路线 （共 9 条）
反应条件
lithium chloride in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Genoni, Andrea; Benaglia, Maurizio; Massolo, Elisabetta; Rossi, Sergio
Chemical Communications, 2013 , vol. 49, # 75 p. 8365 - 8367
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C;
参考文献
Kan, Jovi Tze Wai; Toy, Patrick
Tetrahedron Letters, 2004 , vol. 45, # 33 p. 6357 - 6359
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Valls-Miret, Mariona; Bradley, Mark
Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6819 - 6822
反应条件
1: 100 percent / imidazole / dimethylformamide / 0 - 20 °C 2: 56 percent / Mg / tetrahydrofuran / 20 °C 3: 90 percent / TBAF / tetrahydrofuran / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 33 p. 6357 - 6359
反应条件
1: 56 percent / Mg / tetrahydrofuran / 20 °C 2: 90 percent / TBAF / tetrahydrofuran / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 33 p. 6357 - 6359
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 12 h; Reflux;
参考文献
Tetrahedron Letters, , vol. 54, # 33 p. 4483 - 4486
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 4 h / |Acidic conditions 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 12 h / |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 33 p. 4483 - 4486
反应条件
sodium tetrahydroborate in 1,4-dioxane; isopropyl alcohol
T=20°C; Rate constant;
参考文献
AMGEN INC.
Patent: WO2007/61670 A1, 2007 ;
Location in patent: Page/Page column 168-169 ;
WO 2007/061670 A1
