N-叔丁氧羰基-5-溴吲哚合成路线 （共 13 条）
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 3 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1731505 A1, 2006 ;
Location in patent: Page/Page column 29-30 ;
EP 1731505 A1
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C;
参考文献
THE TRUSTEES OF COLLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Patent: WO2006/26368 A2, 2006 ;
Location in patent: Page/Page column 91-92 ;
反应条件
anhydrous copper acetate; caesium carbonate; N-methyl-2-(methylamino)ethylamine in toluene T=110°C; 24 h; Inert atmosphere;
参考文献
Hodgkinson, Roy C.; Schulz, Jurgen; Willis, Michael C.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 3 p. 432 - 434
反应条件
tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; tri-isobutyl aluminium; butanone; potassium bromide in toluene T=100°C; 24 h; Inert atmosphere;
参考文献
Shen, Xiaoqiang; Hyde, Alan M.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2010 , vol. 132, # 40 p. 14076 - 14078
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran T=0 - 5°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran Further stages.;
参考文献
Vazquez, Enrique; Davies, Ian W.; Payack, Joseph F.
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7551 - 7552
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 48 h;
参考文献
Prieto, Monica; Zurita, Esther; Rosa, Esmeralda; Munoz, Lourdes; Lloyd-Williams, Paul; Giralt, Ernest
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6812 - 6820
反应条件
1: With potassium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: With tert.-butyl lithium in tetrahydrofuran; pentane 0.183333 h; 3: With boric acid trimethyl ester in tetrahydrofuran; pentane T=-78 - 20°C;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.
Organic Letters, 2012 , vol. 14, # 18 p. 4814 - 4817,4
反应条件
sodium methylate in methanol T=20°C; 0.5 h;
参考文献
Ravinder; Reddy, A. Vijender; Mahesh, K. Chinni; Narasimhulu; Venkateswarlu
Synthetic Communications, 2007 , vol. 37, # 2 p. 281 - 287
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); 1,1,1,2,2,2-hexabutyl-distannane; lithium chloride in 1,4-dioxane T=23 - 100°C; Inert atmosphere; 2: With silver trifluoromethanesulfonate; F-TEDA-PF6 in acetone T=23°C; 0.333333 h; Inert atmosphere; regiospecific reaction;
参考文献
Furuya, Takeru; Strom, Alexandra E.; Ritter, Tobias
Journal of the American Chemical Society, 2009 , vol. 131, p. 1662 - 1663
反应条件
1: KOAc; PdCl2(dppf) / dioxane / 48 h / 100 °C 2: K3PO4; PdCl2(dppf) / dioxane / 72 h / 100 °C View Scheme
参考文献
Prieto, Monica; Zurita, Esther; Rosa, Esmeralda; Munoz, Lourdes; Lloyd-Williams, Paul; Giralt, Ernest
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6812 - 6820
