N-叔丁氧羰基-5-溴吲哚合成路线 （共 13 条）
反应条件
potassium carbonate; copper(l) iodide; bis(η3-allyl-μ-chloropalladium(II)); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran; N,N-dimethyl-formamide
T=75°C; 46 h; Product distribution / selectivity;
参考文献
Nakao, Yoshiaki; Hiyama, Tamejiro
Patent: US2009/69577 A1, 2009 ;
Location in patent: Page/Page column 21; 24 ;
反应条件
1: palladium diacetate / methanol / Reflux
2: trifluoroacetic acid / dichloromethane / 25 °C
View Scheme
参考文献
Pandya, Vrajesh; Jain, Mukul; Chakrabarti, Ganes; Soni, Hitesh; Parmar, Bhavesh; Chaugule, Balaji; Patel, Jigar; Joshi, Jignesh; Joshi, Nirav; Rath, Akshyaya; Raviya, Mehul; Shaikh, Mubeen; Sairam, Kalapatapu V.V.M.; Patel, Harilal; Patel, Pankaj
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5701 - 5706
反应条件
1: 5-Bromo-indole-1-carboxylic acid tert-butyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Inert atmosphere;
2: tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78°C; 0.75 h;
3: carbon dioxide
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2108642 A1, 2009 ;
Location in patent: Page/Page column 77 ;
