2-联苯-(2-甲氧基)乙酸合成路线 (共 8 条)
反应条件
1: With potassium carbonate; iron oxide nanoparticle-Pd complex in N,N-dimethyl-formamide
T=80°C; Suzuki Coupling; 144 h; Polystyrene resin;
2: With sodium hydroxide in ethanol; water
48 h; Reflux;
参考文献
SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
Patent: US2011/190506 A1, 2011 ;
Location in patent: Page/Page column 12-13; sheet 11/11 ;
反应条件
1: 2-(2-iodophenyl)acetic acid With chloromethyl polystyrene; cross-linked with divinylbenzene; potassium carbonate in N,N-dimethyl-formamide
T=85°C; 24 h;
2: 2-Methoxyphenyl-dihydroxyborane With potassium carbonate; nanoparticle-supported homogeneous Pd-catalyst in N,N-dimethyl-formamide
T=80°C; Suzuki cross-coupling; 144 h;
3: With sodium hydroxide in methanol; water
48 h; Heating;
参考文献
Zheng, Yan; Stevens, Philip D.; Gao, Yong
Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 537 - 542
反应条件
potassium hydroxide in ethanol
24 h; Heating;
参考文献
Suau, Rafael; Lopez-Romero, Juan Manuel; Rico, Rodrigo; Alonso, Francisco J.; Lobo, Carolina
Tetrahedron, 1996 , vol. 52, # 34 p. 11307 - 11320
反应条件
1: 64 percent / K2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 18 h / Heating
2: KOH / H2O / 0.5 h / Heating
View Scheme
参考文献
Suau; Rico; Najera; Ortiz-Lopez; Lopez-Romero; Moreno-Manas; Roglans
Tetrahedron, 2004 , vol. 60, # 27 p. 5725 - 5735
反应条件
1: 64 percent / K2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 18 h / Heating
2: KOH / H2O / 0.5 h / Heating
View Scheme
参考文献
Suau; Rico; Najera; Ortiz-Lopez; Lopez-Romero; Moreno-Manas; Roglans
Tetrahedron, 2004 , vol. 60, # 27 p. 5725 - 5735
反应条件
1: 95 percent / KOH / acetonitrile / 12 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
3: SOCl2 / various solvent(s) / 0.5 h / Ambient temperature
4: acetonitrile / 48 h / Heating
5: 94 percent / aq. KOH / ethanol / 24 h / Heating
View Scheme
参考文献
Suau, Rafael; Lopez-Romero, Juan Manuel; Rico, Rodrigo; Alonso, Francisco J.; Lobo, Carolina
Tetrahedron, 1996 , vol. 52, # 34 p. 11307 - 11320
反应条件
1: LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
2: SOCl2 / various solvent(s) / 0.5 h / Ambient temperature
3: acetonitrile / 48 h / Heating
4: 94 percent / aq. KOH / ethanol / 24 h / Heating
View Scheme
参考文献
Suau, Rafael; Lopez-Romero, Juan Manuel; Rico, Rodrigo; Alonso, Francisco J.; Lobo, Carolina
Tetrahedron, 1996 , vol. 52, # 34 p. 11307 - 11320
反应条件
1: SOCl2 / various solvent(s) / 0.5 h / Ambient temperature
2: acetonitrile / 48 h / Heating
3: 94 percent / aq. KOH / ethanol / 24 h / Heating
View Scheme
参考文献
Suau, Rafael; Lopez-Romero, Juan Manuel; Rico, Rodrigo; Alonso, Francisco J.; Lobo, Carolina
Tetrahedron, 1996 , vol. 52, # 34 p. 11307 - 11320