1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-68°C; 1.66667 h; 2: iso-butyronitrile in tetrahydrofuran; hexane T=-70°C; 2 h; 3: 2-bromoacetaldehyde diethyl acetal With N,N'-dimethyl-N,N'-propyleneurea more than 3 stages;

1: 3-cyanopropionaldehyde diethyl acetal With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.55 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; hexane T=-78 - 0°C; Inert atmosphere;

potassium in N,N,N',N',N'',N''-hexamethylphosphoric triamide; diethyl ether T=0°C;