1: diethyl ether 2: PBr3; pyridine; petroleum ether / Schuetteln des entstandenen Bromids mit Kaliumacetat in Aceton und Verseifen des entstandenen Acetats mit methylalkoholischer KOH 3: PtO2; acetic acid ester / Hydrogenation.zuletzt in Eisessig View Scheme

2: 85 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / Heating 3: 96 percent / HCl, KF, MeOH / CH2Cl2 / 2 h / Ambient temperature 4: 59 percent / H2O2, NaHCO3, H2O / methanol; tetrahydrofuran / 12 h / Heating View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 50 percent / Et₃N, DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature<br />2: 38 percent / diethyl ether; tetrahydrofuran / 9 h / Ambient temperature<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4267587', constants.ctx, '0')">potassium carbonate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />72&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '741873', constants.ctx, '0')">prenyl bromide</a>; <a href="#" onclick="return RXDsubstances(event, this, '741937', constants.ctx, '0')">acetylacetone</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a> <br /> <br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '1209228', constants.ctx, '0')">formaldehyd</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4267587', constants.ctx, '0')">potassium carbonate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=0 - 20&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>2: 89 percent / KOH, H₂O / ethanol / 1.5 h / Heating<br />3: 50 percent / Et₃N, DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature<br />4: 38 percent / diethyl ether; tetrahydrofuran / 9 h / Ambient temperature<br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />9&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4933359', constants.ctx, '0')">sodium amide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '5136723', constants.ctx, '0')">sodium sulfate</a> <br />&nbsp;Reagens 4: Benzol;&nbsp;<br /> &nbsp;