1: thien-2-yl bromide With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78 - 0°C; 0.0833333 h; 2: chloro-trimethyl-silane in tetrahydrofuran T=-78 - 20°C; 0.5 h;

in tetrahydrofuran; hexanes 1 h; Cooling with acetone-dry iceInert atmosphere;

diethyl ether; magnesium anschliessend Behandeln mit wss. Salzsaeure;

aluminum tri-bromide; PhSeOCl in dichloromethane 3 h; Ambient temperature; Further byproducts given;

n-butyllithium 1. THF/-50 - -55 deg C/30 min 2. THF/-50 - -55 deg C; Yield given. Multistep reaction. Yields of byproduct given;

aluminum tri-bromide in chloroform Further byproducts given;

aluminum tri-bromide in dichloromethane Further byproducts given;

diethyl ether; magnesium anschliessend Behandeln mit festem Kohlendioxid;

1: With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: With copper dichloride in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere;

aluminium in N,N-dimethyl-formamide byproducts: Al(3+); Electrolysis; electrolysis carried out in a single-compartment cell at room temp., starting materials dissolved in DMF containing KBr or n-Bu4NBr, solvent andexcess B(OCH3)3 evaporated under vacuum, medium hydrolysed at 0° C with an HCl or H2SO4 soln.; extraction with Et2O (3 x 20 ml if the solvent evaporated or 3 x 60 ml otherwise), dried over sodium or magnesium sulfate and concentrated undervacuum, side product phenol formation avoided by work-up under inert at mosphere, recrystallized in CH2Cl2;