N-苯甲酰基-2'-O-甲氧基乙基-5-O-二甲氧基三苯甲基-5-甲基胞苷合成路线 （共 10 条）
反应条件
1: in DMF (N,N-dimethyl-formamide)
T=20°C; 21 h;
2: With sodium hydride; dimethyl sulfoxide in toluene
T=20°C; 1 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232770 A1, 2003 ;
Location in patent: Page 21 ;
反应条件
1: in DMF (N,N-dimethyl-formamide)
T=20°C; 38 h;
2: With triethylamine in DMF (N,N-dimethyl-formamide); toluene
0.0166667 h;
3: With sodium hydride in dimethyl sulfoxide; toluene; oil
T=20°C; 1 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/225012 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
1: in DMF (N,N-dimethyl-formamide)
T=20°C; 16 h;
2: With sodium hydride in dimethyl sulfoxide
T=20°C; 1 h;
参考文献
Monia, Brett P.; Freier, Susan M.; Manoharan, Muthiah; Gaarde, William A.; Griffey, Richard H.; Swayze, Eric E.; Bennett, C. Frank
Patent: US2005/130924 A1, 2005 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
benzoic acid anhydride in DMF (N,N-dimethyl-formamide)
T=20°C; 21 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232771 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
triethanolamine in water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/198965 A1, 2003 ;
Title/Abstract Full Text Show Details
Dobie, Kenneth W.; Koller, Erich
Patent: US2003/220275 A1, 2003 ;
反应条件
in N,N-dimethyl-formamide
3 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/77085 A1, 2004 ;
Location in patent: Page/Page column 17 ;
反应条件
1.1: 75 percent / B(OCH2CH2OCH3)3; NaHCO3 / 18 h / 130 °C / atmospheric pressure
2.1: pyridine
3.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
3.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
3.3: aq. NH3 / dioxane / 25 °C
4.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
1.1: pyridine
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
2.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
2.3: aq. NH3 / dioxane / 25 °C
3.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
1.1: 96 percent / 2,6-lutidine / acetonitrile / -10 - 0 °C
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
2.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
2.3: aq. NH3 / dioxane / 25 °C
3.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
1.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 5 °C
1.2: phosphorus oxychloride; 1,2,4-triazole / -20 - 5 °C
1.3: aq. NH3 / dioxane / 25 °C
2.1: dimethylformamide / 24 h / 25 °C
View Scheme
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
