4-(4-硝基苯基)哌嗪-1-羧酸叔丁酯合成路线 (共 14 条)
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C;
参考文献
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA
Patent: WO2006/38039 A1, 2006 ;
Location in patent: Page/Page column 17; 30 ;
反应条件
N-ethyl-N,N-diisopropylamine in 1,4-dioxane
参考文献
Chen, Li; Ding, Qingjie; Gillespie, Paul; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoye; Perrotta, Agostino
Patent: US2002/151554 A1, 2002 ;
反应条件
triethylamine in dichloromethane T=20°C; 20 h;
参考文献
CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; CHOI, Neil; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter
Patent: WO2014/26242 A1, 2014 ;
Location in patent: Page/Page column 77 ;
反应条件
1: With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate in xylene T=50°C; 2: With macroporous polymer-supported isocyanate in xylene T=50°C; 24 h;
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
反应条件
triethylamine in dichloromethane; water
反应条件
in dichloromethane; ethyl acetate
参考文献
Booth, Richard John; Dobrusin, Ellen Myra; Josyula, Vara Prasad Venkata Nagendra; McNamara, Dennis Joseph; Toogood, Peter Laurence
Patent: US2003/73668 A1, 2003 ;
US 20030073668 A1
参考文献
US2003/73668 A1, ;
US 20030073668 A1
反应条件
potassium carbonate in dimethyl sulfoxide T=90°C; 12 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 75, p. 43 - 56
反应条件
1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 2: triethylamine / dichloromethane / 1 h / 0 - 5 °C 3: hydrogen / palladium 10 on activated carbon / methanol / 20 °C View Scheme
参考文献
WO2012/59932 A1, ;
WO 2012/059932 A1
反应条件
1: With Amberlyst(R) 15 in dichloromethane T=20°C; 2: With ammonium hydroxide in methanol T=20°C; 1.5 h;
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552