反应条件
1.1: 84 percent / bromotrimethylsilane / CH2Cl2 / 12 h / 20 °C 2.1: Mg / tetrahydrofuran / 20 °C 2.2: Li2CuCl4 / tetrahydrofuran / -78 °C 2.3: 55 percent / tetrahydrofuran / 17 h / -78 - 20 °C 3.1: 90 percent / pyridinium p-toluenesulfonate; ethanol / 3 h / 50 °C 4.1: 96 percent / N,N-(dimethylamino)pyridine / CH2Cl2 / 16 h 5.1: Mg / tetrahydrofuran / 20 °C 5.2: Li2CuCl4 / tetrahydrofuran / -78 °C 5.3: 64 percent / tetrahydrofuran / 15 h / -78 - 20 °C View Scheme
参考文献
Pinchuk, Anatoly N.; Rampy, Mark A.; Longino, Marc A.; Skinner, R. W. Scott; Gross, Milton D.; Weichert, Jamey P.; Counsell, Raymond E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2155 - 2165
