反应条件
1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran; methanol / 74.5 h / 0 - 20 °C / Cooling with ice 3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Cooling with ice 4: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere View Scheme
参考文献
Demont, Emmanuel H.; Arpino, Sandra; Bit, Rino A.; Campbell, Colin A.; Deeks, Nigel; Desai, Sapna; Dowell, Simon J.; Gaskin, Pam; Gray, James R. J.; Harrison, Lee A.; Haynes, Andrea; Heightman, Tom D.; Holmes, Duncan S.; Humphreys, Philip G.; Kumar, Umesh; Morse, Mary A.; Osborne, Greg J.; Panchal, Terry; Philpott, Karen L.; Taylor, Simon; Watson, Robert; Willis, Robert; Witherington, Jason
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6724 - 6733