1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
1: citric acid With chlorosulfonic acid in dichloromethane T=10 - 15°C; 5 - 6 h; 2: methanol in dichloromethane T=3 - 35°C; 2 h; Conversion of starting material;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: WO2004/89867 A2, 2004 ;
Location in patent: Page 20-26 ;
反应条件
hydrogenchloride; 1,1'-carbonyldiimidazole in tetrahydrofuran; ethyl acetate
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
lithium diisopropyl amide in tetrahydrofuran; hexane T=-45°C; 1.) 30 min, 2.) 90 min;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 108, # 2 p. 51 - 56
反应条件
sulfuric acid; sulfur trioxide Behandeln des Reaktionsgemisches mit Methanol.;
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1385,1388, 1392
Journal of Organic Chemistry, , vol. 23, p. 391,393
US2887508 , ;
参考文献
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 121, p. 146
Annales de Chimie (Cachan, France), , vol. <6> 23, p. 165
Chemische Berichte, , vol. 49, p. 2704
Chemische Berichte, , vol. 53, p. 1917
反应条件
sulfuric acid 1.) 20-25 deg C, 3 h; 45 deg C, 6 h, 2.) 35-40 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 37, # 4 p. 397 - 398
参考文献
Roczniki Chemii, vol. 7, p. 583
Chem. Zentralbl., , vol. 99, # II p. 448
反应条件
1: NaBH4 / methanol 2: KOH / methanol 3: H2SO4 View Scheme
参考文献
Cohen,S.C.; Khedouri,E.
Journal of the American Chemical Society, 1961 , vol. 83, p. 4228 - 4233
反应条件
1.1: triethylamine; 4-Acetylaminobenzenesulfonyl Azide / acetonitrile / 1 h / 0 - 20 °C 2.1: triphenylphosphine / diethyl ether / 24 h / 20 °C 2.2: 10 h / |Reflux 3.1: trichlorophosphate / 5 h / 95 °C View Scheme
反应条件
1: methanol. KOH-solution / 0 °C 2: aqueous methanol. NaOH View Scheme
参考文献
Findlay
Journal of Organic Chemistry, 1957 , vol. 22, p. 1385,1388, 1392
Journal of Organic Chemistry, 1958 , vol. 23, p. 391,393
