1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
potassium fluoride; water; Fe2(CO)9; acetic acid
1.) benzene, 45 deg C, 30 min, 2.) benzene, reflux, 12 h; Yield given. Multistep reaction;
参考文献
Takeuchi, Naoki; Okazaki, Kousuke; Ohki, Junji; Tobinaga, Seisho
Heterocycles, 1984 , vol. 21, # 2 p. 615
反应条件
ammonium acetate; sodium cyanoborohydride; acetic acid in methanol
参考文献
Lesma, Giordano; Danieli, Bruno; Sacchetti, Alessandro; Silvani, Alessandra
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3317 - 3320
反应条件
ammonium formate in hydrogenchloride; methanol; dichloromethane
参考文献
G. D. Searle and Co.
Patent: US5625093 A1, 1997 ;
反应条件
1.1: NH4Cl; 3 Angstroem molecular sieves / methanol / 12 h
1.2: NaBH3CN; HCl / methanol / pH 3
2.1: 30.29 g / aq. K2CO3 / diethyl ether / 3 h / 20 °C
View Scheme
参考文献
Ohno, Masaji; Kobayashi, Susumu; Iimori, Takamasa; Wang, Yi-Fong; Izawa, Toshio
Journal of the American Chemical Society, 1981 , vol. 103, # 9 p. 2405 - 2406
反应条件
phosphorus pentachloride
T=50°C; 0.5 h;
参考文献
Afarinkia, Kamyar; Bearpark, Michael J.; Ndibwami, Alexis
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7158 - 7166
反应条件
1: 0-10 deg C
2: acetonitrile / 1 h / Heating
3: 99 percent / triethylamine / CH2Cl2 / 1 h / -10 - -5 °C
4: 90 percent / NaI / acetonitrile / 1 h / Heating
5: 95 percent / NaH / dimethylformamide / 1 h / 0 deg C -> r.t.
6: 89 percent / 85percent KOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
morpholine; sulfur in methanol
T=40°C; 2 h; Heating / reflux;
参考文献
Vaysse-Ludot, Lucile; Lecouve, Jean-Pierre; Langlois, Pascal
Patent: US2004/59135 A1, 2004 ;
Location in patent: Page 2 ;
反应条件
1: methanol / 10 - 70 °C
2: sulfur / methanol / 2 h / 65 - 70 °C
View Scheme
参考文献
FLEMING LABORATORIES LIMITED; BALASUBRAMANIAM, Ravishankar; POLSANI, Pulla Rao; TOGATA, Madduleti
Patent: WO2013/175270 A1, 2013 ;
反应条件
4-Acetylaminobenzenesulfonyl Azide; triethylamine in dichloromethane
T=0 - 20°C; 1.5 h;
参考文献
Supurgibekov, Murat B.; Prakash, G.K. Surya; Nikolaev, Valerij A.
Synthesis (Germany), 2013 , vol. 45, # 9 p. 1215 - 1226
反应条件
triethylamine in diethyl ether; hexane; acetonitrile
参考文献
Yamada, Koichiro; Matsuki, Kenji; Omori, Kenji; Kikkawa, Kohei
Patent: US2004/142930 A1, 2004 ;
US 20040142930 A1
