1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
1: 66 percent / pTsOH / tetrahydrofuran / 48 h / 70 °C
2: 82 percent / DIBAL / CH2Cl2 / 2 h / -78 °C
View Scheme
参考文献
Jung, Mankil; Miller, Marvin J.
Tetrahedron Letters, 1985 , vol. 26, # 8 p. 977 - 980
反应条件
in water
T=20°C; Mannich reaction; 16 h;
参考文献
Diwischek, Florian; Arnone, Mario; Engels, Bernd; Holzgrabe, Ulrike
Tetrahedron, 2005 , vol. 61, # 29 p. 6993 - 7001
反应条件
1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C
2: 92 percent / NH3 / methanol / 0 °C
3: 95 percent / K2CO3 / acetone / Heating
4: 78 percent / tetrahydrofuran / Heating
View Scheme
参考文献
Smith, Roger A.; Hertzog, Donald L.; Osterhout, Martin H.; Ladouceur, Gaetan H.; Korpusik, Mary; Bobko, Mark A.; Jones; Phelan, Kathleen; Romero, Romulo H.; Hundertmark, Thomas; MacDougall, Margit L.; Livingston, James N.; Schoen, William R.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 9 p. 1303 - 1306
反应条件
sulfuryl dichloride
Erwaermen des Reaktionsgemisches mit Triaethylphosphit;
参考文献
Allied Chem.Corp.
Patent: US2891887 , 1957 ;
反应条件
in benzene
18 h; Heating;
参考文献
Yamagiwa, Yoshiro; Koreishi, Yoshiro; Kiyozumi, Satoshi; Kobayashi, Masanori; Kamikawa, Tadao; Tsukino, Mitsuji; Goi, Hironori; Yamamoto, Mikiko; Munakata, Megumu
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 11 p. 3317 - 3323
反应条件
in toluene
T=100°C; 36 h;
参考文献
Storey, Anthony; Davis, Julie; Ricketts, Sally-Ann; Medizabal, Marivi; Cuthbertson, Alan; Arukwe, Joseph; Heywood, Kirsty; Wilson, Ian; Wynn, Duncan; Schafers, Michael; Levkau, Bodu; Wagner, Stefan; Breyholz, Hans-Jorg; Kopka, Klaus
Patent: US2007/71670 A1, 2007 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 88 percent / benzene / 18 h / Heating
2: 99 percent / H2 / 1percent PtO2/C / ethanol
View Scheme
参考文献
GE HEALTHCARE LIMITED; Indrevoll, Bard; Hiscock, Duncan; Arbo, Bente Elizabeth; Bhalla, Rajiv; Glaser, Matthias Eberhard; McRobbie, Graeme Walter
Patent: US2013/189186 A1, 2013 ;
反应条件
sulfuric acid
T=90°C; 0.5 h;
参考文献
Besson, Thierry; Joseph, Benoit; Moreau, Pascale; Viaud, Marie-Claude; Coudert, Gerard; Guillaumet, Gerald
Heterocycles, 1992 , vol. 34, # 2 p. 273 - 291
反应条件
1: conc. HCl, amyl nitrite
2: glacial acetic acid, zinc, ammonium acetate / 4 h / 60 °C
View Scheme
参考文献
Smith, Kevin M.; Fujinari, Eugene M.; Pandey, Ravindra K.; Tabba, Hani D.
Journal of Organic Chemistry, 1986 , vol. 51, # 24 p. 4667 - 4676
参考文献
Kepe, Vladimir; Kocevar, Marijan; Petric, Andrej; Polanc, Slovenko; Vercek, Bojan
Heterocycles, 1992 , vol. 33, # 2 p. 843 - 849
