1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
acetic anhydride
130 deg C, reduced during 1 h to 120 deg C;
参考文献
Leard, Robert E.; Bedenbaugh, John H.; Bedenbaugh, Angela O.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1363 - 1366
反应条件
1.1: 89 percent / BF3*Et2O / CH2Cl2 / 8 h / 20 °C
2.1: 100 percent / LiAlH4 / tetrahydrofuran / 12 h
3.1: 92 percent / TsOH / CH2Cl2 / 0 °C
4.1: 90 percent / HgCl2; CaCO3 / acetonitrile; H2O / 2 h / 20 °C
5.1: Mg / diethyl ether
5.2: 90 percent / diethyl ether / 2.5 h / Heating
6.1: 85 percent / TsOH / methanol / 4 h / Heating
7.1: 0.5 g / Ag2CO3 / methanol; benzene / 6 h / Heating
View Scheme
参考文献
Mohanty, Sasank Sekhar; Uebelhart, Peter; Eugster, Conrad Hans
Helvetica Chimica Acta, 2000 , vol. 83, # 8 p. 2036 - 2053
反应条件
1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C
2: 92 percent / NH3 / methanol / 0 °C
3: 95 percent / K2CO3 / acetone / Heating
4: 78 percent / tetrahydrofuran / Heating
5: Red-Al<*> / tetrahydrofuran / 20 °C
6: PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1: 60 percent / HCl / methanol / 3 h
2: 88 percent / K2CO3 / acetone / 1 h / 50 - 56 °C
View Scheme
参考文献
Dubovik; Garazd; Khilya
Chemistry of Natural Compounds, 2004 , vol. 40, # 5 p. 434 - 443
反应条件
1: 72 percent / AcONH4, AcOH / benzene / 6 h / 130 - 135 °C
2: KOH / ethanol / 48 h / 0 °C
3: PCl5 / CH2Cl2 / 9 h / 25 °C
5: 10 percent / H+ / dioxane / 17 h / 96 °C
View Scheme
参考文献
Curran, Dennis P.; Liu, Hui; Josien, Hubert; Ko, Sung-Bo
Tetrahedron, 1996 , vol. 52, # 35 p. 11385 - 11404
反应条件
ammonium hydrogen carbonate in methanol; Me-THF
T=20°C; 18 h;
参考文献
Cleary, Thomas; Ji, Yaohui; Lee, Gary R.; Rawalpally, Thimma; Sarma, Keshab
Patent: US2008/312467 A1, 2008 ;
Location in patent: Page/Page column 3; 5 ;
US 20080312467 A1
参考文献
Specht, Donald P.; Martic, Peter A.; Farid, Samir; ++
Tetrahedron, 1982 , vol. 38, # 9 p. 1203 - 1211
参考文献
Specht, Donald P.; Martic, Peter A.; Farid, Samir; ++
Tetrahedron, 1982 , vol. 38, # 9 p. 1203 - 1211
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/124595 A1, 2009 ;
Location in patent: Page/Page column 33 ;
US 20090124595 A1
反应条件
1: 88 percent / benzene / 18 h / Heating
2: 99 percent / H2 / 1percent PtO2/C / ethanol
3: 86 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Yamagiwa, Yoshiro; Koreishi, Yoshiro; Kiyozumi, Satoshi; Kobayashi, Masanori; Kamikawa, Tadao; Tsukino, Mitsuji; Goi, Hironori; Yamamoto, Mikiko; Munakata, Megumu
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 11 p. 3317 - 3323
