1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
1: 70 percent 2: 95 percent / NaOH / ethanol View Scheme
参考文献
Curran, Dennis P.; Liu, Hui; Josien, Hubert; Ko, Sung-Bo
Tetrahedron, 1996 , vol. 52, # 35 p. 11385 - 11404
反应条件
1: With sodium carbonate in water T=20°C; 67 h; 2: With hydrogenchloride in water; acetic acid 3.5 h; Heating;
参考文献
Heubes; Dietz; Quast; Seefelder; Witzel; Gadgil; Williams
Journal of Organic Chemistry, 2001 , vol. 66, # 6 p. 1949 - 1960
反应条件
1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C 2: 92 percent / NH3 / methanol / 0 °C 3: 95 percent / K2CO3 / acetone / Heating 4: 78 percent / tetrahydrofuran / Heating 5: Red-Al<*> / tetrahydrofuran / 20 °C 6: PCC / CH2Cl2 / 20 °C 7: tetrahydrofuran / 20 °C 8: LiAlH4 / tetrahydrofuran / 20 °C 9: PCC / CH2Cl2 / 20 °C View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1.1: sodium nitrite; acetic acid / water / 0 - 20 °C 2.1: hydrogen / palladium 10 on activated carbon / 3 h / 20 °C 3.1: thionyl chloride / chloroform / 0 °C / Reflux 3.2: 0 °C View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238599 A1, 2012 ;
US 20120238599 A1
反应条件
manganese triacetate in acetic acid 0.05 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 57, # 13 p. 3551 - 3557
反应条件
1: T=20 - 70°C; 2: T=100°C; 1.5 h;
参考文献
Bevk, David; Jakse, Renata; Svete, Jurij; Golobic, Amalija; Golic, Ljubo; Stanovnik, Branko
Heterocycles, 2003 , vol. 61, p. 197 - 223
反应条件
1.1: acetic anhydride / 2 h / 130 °C 1.2: 1 h / 0 °C 1.3: 0.33 h / 20 °C 2.1: N,N-diethylaniline; trichlorophosphate / 21 h / 20 °C / Reflux 3.1: methanol / 3 h / 0 - 20 °C View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; GAJERA, Jitendra Maganbhai; NARAYANA, Lakshminarayana; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2012/110860 A1, 2012 ;
WO 2012/110860 A1
反应条件
1: 1.) sodium bisulfite / H2O / Ambient temperature; 1.) 20 min, 2.) 1 h 2: 13 N HCl / 15 h / Heating View Scheme
参考文献
Winkel, C.; Buitenhuis, E. G.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1989 , vol. 108, # 2 p. 51 - 56
反应条件
1: 66 percent / H2SO4 / 0.5 h / 90 °C 2: 78 percent / NaOH / H2O / 12 h / Heating View Scheme
参考文献
Besson, Thierry; Joseph, Benoit; Moreau, Pascale; Viaud, Marie-Claude; Coudert, Gerard; Guillaumet, Gerald
Heterocycles, 1992 , vol. 34, # 2 p. 273 - 291
反应条件
1: With acetic anhydride; acetic acid T=120°C; 1.5 h; 2: With ammonia in water 1 h; Cooling with ice; 3: With hydrogenchloride in water
参考文献
Luk, Kin-Chun
Patent: US2012/184562 A1, 2012 ;
Location in patent: Page/Page column 6; 17 ;
US 20120184562 A1
