1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
1: With acetic anhydride; orthoformic acid triethyl ester T=130°C; 1.5 h; 2: With ammonia in water T=0°C; 1 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/217417 A1, 2006 ;
Location in patent: Page/Page column 12 ;
反应条件
1.1: acetic anhydride / 2 h / 130 °C 1.2: 1 h / 0 °C 1.3: 0.33 h / 20 °C 2.1: N,N-diethylaniline; trichlorophosphate / 21 h / 20 °C / Reflux 3.1: methanol / 3 h / 0 - 20 °C 4.1: lithium hydroxide hydrate / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; GAJERA, Jitendra Maganbhai; NARAYANA, Lakshminarayana; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2012/110860 A1, 2012 ;
WO 2012/110860 A1
反应条件
1: 54 percent / NaBH4 2: 95 percent / KOH / methanol / 2 h View Scheme
参考文献
Cohen,S.C.; Khedouri,E.
Journal of the American Chemical Society, 1961 , vol. 83, p. 4228 - 4233
反应条件
lithium bromide in 1,4-dioxane 20 h; Reflux;
参考文献
Tetrahedron, , vol. 67, # 45 p. 8679 - 8684
反应条件
1: 90 percent / TMSCl / CH2Cl2 / Heating 2: 80 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 29 p. 4907 - 4911
反应条件
1: 60 percent / HCl / methanol / 3 h 2: 88 percent / K2CO3 / acetone / 1 h / 50 - 56 °C 3: 74 percent / aq. KOH / 1 h / 20 °C View Scheme
参考文献
Dubovik; Garazd; Khilya
Chemistry of Natural Compounds, 2004 , vol. 40, # 5 p. 434 - 443
参考文献
Specht, Donald P.; Martic, Peter A.; Farid, Samir; ++
Tetrahedron, 1982 , vol. 38, # 9 p. 1203 - 1211
反应条件
sodium tetrahydroborate; citric acid in methanol T=20°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Riatto, Valeria B.; Carneiro, Maria N. M.; Carvalho, Venilia B.; Victor, Mauricio M.
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 1 p. 172 - 175
反应条件
sodium methylate 1.) MeOH, r.t., overnight, 2.) baker's yeast, H2O, 40 deg C; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Arslan, Tuncer; Benner, Steven A.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2260 - 2264
反应条件
sodium methylate 1.) MeOH, r.t., overnight, 2.) baker's yeast, H2O, 40 deg C; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Arslan, Tuncer; Benner, Steven A.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2260 - 2264
