1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
1: With potassium hydroxide in ethanol 2: With acetic anhydride in acetic acid
参考文献
Synlett, , # 5 art. no. D01105ST, p. 860 - 862
反应条件
1: methanol 2: TsOH / benzene View Scheme
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 1986 - 1993
反应条件
ammonium acetate; acetic acid in benzene 24 h; Reflux;
参考文献
Canadillas-Delgado, Laura; Martin, Tomas; Fabelo, Oscar; Pasan, Jorge; Delgado, Fernando S.; Lloret, Francesc; Julve, Miguel; Ruiz-Perez, Catalina
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 4037 - 4047
反应条件
1: NaBH4 / methanol 2: p-TsOH*H2O / diethyl ether View Scheme
参考文献
Mori, Kenji; Ikunaka, Masaya
Tetrahedron, 1987 , vol. 43, # 1 p. 45 - 58
反应条件
1: 1.) ammonium acetate, molecular sieves 3 Angstroem, 2.) methanolic HCl, NaBH3CN / 1.) methanol, 2 d, 2.) pH 3, r.t., 1 h 2: 84 percent / aq. NaHCO3 / toluene / 3 h / Ambient temperature 3: 82 percent / phosphate buffer, aq. NaOH / pig liver esterase / acetone / 7 h / 25 °C / pH 8 4: 83 percent / 4-dimethylaminopyridine, dicyclohexylcarbodiimide / CH2Cl2 / 1.) 0 deg C, 5 min, 2.) r.t., 3 h 5: 81 percent / aq. NaOH / methanol / 2.5 h / Ambient temperature 6: 67 percent / 2-isobutyloxy-1-isobutyloxycarbonyl-1,2-dihydroquinoline / tetrahydrofuran / 1.) r.t., 2.) reflux 7: 76 percent / CF3COOH / CH2Cl2 / 1.5 h / Ambient temperature 8: 30 percent / H2 / 10percent Pd-C / methanol / 20 °C View Scheme
参考文献
Crossley, Maxwell J.; Fisher, Megan L.; Potter, Jeffrey J.; Kuchel, Philip W.; York, Michael J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2363 - 2369
反应条件
triethylamine in methanol 24 h; Heating;
参考文献
L'abbe, Gerrit; Dehaen, Wim
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 10 p. 823 - 824
反应条件
sodium hydroxide in methanol
T=25°C; pH: 7;
参考文献
Bertz, Steven H.; Dabbagh, Gary
Angewandte Chemie, 1982 , vol. 94, # 4 p. 317 - 318
反应条件
sodium hydride in tetrahydrofuran
T=-10°C; 2 h;
参考文献
Covarrubias-Zuniga, Adrian; Rios-Barrios, Eduardo
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5688 - 5689
反应条件
potassium fluoride; acetic acid in 1,4-dioxane
Heating;
参考文献
Takeuchi, Naoki; Okada, Naomi; Tobinaga, Seisho
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4355 - 4359
反应条件
triethylamine in tetrahydrofuran
72 h; Heating;
参考文献
Barton, Derek H. R.; Dressaire, Gilles; Willis, Brian J.; Barrett, Anthony G.M.; Pfeffer, Marc
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 665 - 670
