p-(二甲氧基甲基)苯乙醇合成路线 （共 7 条）
反应条件
hydrogenchloride; LiAlH4; p-TsOH.H2 O in tetrahydrofuran; methanol; diethyl ether
反应条件
lithium boron tetrafluoride in methanol T=40°C; 9 h;
参考文献
Synlett, , # 6 p. 1074 - 1076
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Ambient temperature;
参考文献
Helvetica Chimica Acta, , vol. 79, # 6 p. 1710 - 1740
反应条件
1: 99 percent / <Rh(triphos)(MeCN)3>*OTf3 / methanol / 5 h / Ambient temperature 2: 95 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 79, # 6 p. 1710 - 1740
反应条件
hydrogenchloride; thionyl chloride
参考文献
Grice,R.; Owen,L.N.
Journal of the Chemical Society, 1963 , p. 1947 - 1954
反应条件
sulfuric acid; water in tetrahydrofuran T=20°C; 3 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/136756 A1, 2008 ;
Location in patent: Page/Page column 126 ;
WO 2008/136756 A1
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
DiBlasi, Christine M.; Macks, Daniel E.; Tan, Derek S.
Organic Letters, 2005 , vol. 7, # 9 p. 1777 - 1780
