2,4-二溴-6-氟苯甲酸合成路线 （共 3 条）
反应条件
1: 3,5-dibromo-1-fluorobenzene With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2 h; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
Ahmad, Saleem; Ngu, Khehyong
Patent: US2006/178386 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
US 20060178386 A1
反应条件
2,2,6,6-tetramethyl-piperidine; n-butyllithium 1.) THF, hexane, -75 deg C, 2 h, 2.) THF, hexane; Yield given. Multistep reaction;
参考文献
MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.
Patent: WO2010/129379 A1, 2010 ;
Location in patent: Page/Page column 93 ;
WO 2010/129379 A1
反应条件
1: 3-fluoro-1,2,5-tribromobenzene With isopropylmagnesium chloride in tetrahydrofuran T=-40°C; Grignard reaction; 2 h; 2: carbon dioxide in tetrahydrofuran T=-40°C; 1 h; Further stages. Title compound not separated from byproducts.;
参考文献
Menzel, Karsten; Mills, Paul M.; Frantz, Doug E.; Nelson, Todd D.; Kress, Michael H.
Tetrahedron Letters, 2008 , vol. 49, # 3 p. 415 - 418
